SAS | The Power to Know
cq5dam.thumbnail.319.319
White Paper

Use of JMP® for Optimizing a Custom Peptide Microarray to Identify Autoantibodies for Multiple Sclerosis

About this paper

Design of experiment (DOE) was utilized to optimize a peptide microarray to test autoantibodies in serum against various components of the myelin sheath. Incorporating the ideal assay conditions from a single DOE experiment versus multiple sequential experiments resulted in a reproducible serum assay with low variability, low nonspecific background, and a high level of distinction between multiple sclerosis (MS) and normal samples. A minimum set of peptides was found that achieved a sensitivity of 90 percent. Autoantibodies against each individual peptide were elevated in at least 35 percent of the individual MS patients tested.

About SAS

SAS is the leader in analytics. Through innovative software and services, SAS empowers and inspires customers around the world to transform data into intelligence. SAS gives you THE POWER TO KNOW®.

Máte SAS profil? To complete this form automatically Prihlásiť

*
*
*
*
 
*
 
 
  Yes, I would like to receive occasional emails from SAS Institute Inc. and its affiliates about SAS products and services. I understand that I can withdraw my consent at any time by clicking the opt-out link in the emails.

All personal information will be handled in accordance with the SAS Privacy Statement.

 
 

Back to Top