About this paper
Design of experiment (DOE) was utilized to optimize a peptide microarray to test autoantibodies in serum against various components of the myelin sheath. Incorporating the ideal assay conditions from a single DOE experiment versus multiple sequential experiments resulted in a reproducible serum assay with low variability, low nonspecific background, and a high level of distinction between multiple sclerosis (MS) and normal samples. A minimum set of peptides was found that achieved a sensitivity of 90 percent. Autoantibodies against each individual peptide were elevated in at least 35 percent of the individual MS patients tested.
SAS는 분석 부문의 선두 기업입니다. SAS의 혁신적인 소프트웨어와 서비스는 전세계 고객사가 데이터를 기반으로 인텔리전스를 극대화할 수 있도록 지원합니다. SAS는 THE POWER TO KNOW®를 실현합니다.