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Chromosomal Copy Number Analysis of Affymetrix Arrays with JMP Genomics Software

A number of different cancers have been associated with changes in the copy number of sequences within the human genome. This white paper describes how JMP Genomics can be used to identify regions of sequence duplication and/or deletions within human chromosomes. We describe how chromosomal data sets, generated from Affymetrix SNP arrays of a human breast cancer cell line, were analyzed for copy number changes. The paper shows how JMP Genomics was used to identify specific regions that showed either loss of heterozygosity or increases in chromosomal copy number.

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