SAS | The Power to Know
cq5dam.thumbnail.319.319
White Paper

Use of JMP® for Optimizing a Custom Peptide Microarray to Identify Autoantibodies for Multiple Sclerosis

About this paper

Design of experiment (DOE) was utilized to optimize a peptide microarray to test autoantibodies in serum against various components of the myelin sheath. Incorporating the ideal assay conditions from a single DOE experiment versus multiple sequential experiments resulted in a reproducible serum assay with low variability, low nonspecific background, and a high level of distinction between multiple sclerosis (MS) and normal samples. A minimum set of peptides was found that achieved a sensitivity of 90 percent. Autoantibodies against each individual peptide were elevated in at least 35 percent of the individual MS patients tested.

About SAS

SAS helps 80,000 organisations around the world take their data… And do amazing things… We help organisations turn large amounts of data into knowledge they can use, and we do it better than anyone. It’s no wonder an overwhelming majority of customers continue to use SAS year after year. Find out more, Why SAS?

 

Have a SAS profile? To complete this form automatically Sign In

*
*
*
*
 
*
*
 
 

Back to Top